We examined the potential of allicin, a key active component in garlic, to combat yeast infections caused by the fungus Trichosporon asahii. Our investigation focused on how allicin affects not just the growth of the pathogen but also its overall structure and function.
Through various assessments, we observed that allicin significantly slowed the growth of both free-floating and biofilm forms of T. asahii. Additionally, experiments showed improved survival rates in mice suffering from systemic trichosporonosis, underscoring allicin's protective effects.
When we looked deeper, electron microscopy revealed that allicin damaged the cells of T. asahii, disrupting their shape and internal structures. It also triggered an increase in reactive oxygen species (ROS) within the fungal cells, leading to further oxidative stress and ultimately, cell damage. This mechanism suggests that allicin targets the fungus in multiple ways, making it a promising candidate for treatment.
Importantly, our transcriptome analysis revealed that allicin interferes with critical processes such as cell membrane and cell wall biosynthesis, as well as glucose metabolism. These findings illuminate the complex ways allicin can exert its antifungal effects. Overall, our study indicates that allicin from garlic carries significant potential as an alternative treatment for infections associated with T. asahii.